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Gene Therapy
Research conducted at Nagoya University, Medical Department has updated our knowledge about gene therapy
July 17th, 2008
" High-grade gliomas are highly lethal neoplasms representing approximately 20% of all intracranial tumors. Cationic liposome-mediated interferon-beta (IFN-beta) gene transfer has been found to induce regression of experimental glioma," researchers in Nagoya, Japan report. "We have previously performed a pilot clinical trial to evaluate the safety and effectiveness of this IFN-beta gene therapy in five patients with high-grade glioma. Two patients showed more than 50% reduction while others had stable disease 10 weeks after treatment initiation. To identify alterations in gene expression in brain tumors 2 weeks after the gene therapy trial, we used a microarray...
Source: Gene Therapy Weekly (2008-07-17)
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