Gene Therapy Weekly
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Gene Therapy
Research results from RIKEN update understanding of gene therapy
July 17th, 2008
"Inducible/repressible promoters are useful for the maintenance of toxic genes or timely expression. For ectopic expression of cloned genes in the fission yeast Schizosaccharomyces pombe, the thiamine-regulatable nmt1 promoter has been widely used, since the transcriptional activity of this promoter can be controlled by thiamine," researchers in Kawaguchi, Japan report. "However, this property sometimes limits a certain type of research, since the expression inevitably requires cells to be cultivated under the conditions that induce promoter activation. To allow constitutive expression of heterologous genes, we cloned three promoters of cam1(+), tif51(+) and ef1a-c(+)....
Source: Gene Therapy Weekly (2008-07-17)
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