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Gene Therapy Weekly

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Gene Therapy



Scientists at Yonsei University detail research in gene therapy



July 17th, 2008

"A central issue in mediating repression by nuclear hormone receptors is the distinct or redundant function between co-repressors N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptor). To address the functional relationship between SMRT and NCoR in TR (thyroid hormone receptor)-mediated repression, we have identified multiple TR target genes, including BCL3 (B-cell lymphoma 3-encoded protein), Spot14 (thyroid hormone-inducible hepatic protein), FAS (fatty acid synthase), and ADRB2 (beta-adrenergic receptor 2)," scientists in Seoul, South Korea report.

"We demonstrated that siRNA (small interfering RNA) treatment...


Source: Gene Therapy Weekly (2008-07-17)

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