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Apoptosis
Studies from University of Oxford yield new information about apoptosis
July 17th, 2008
According to recent research from Oxford, the United Kingdom, "Osteoblasts depend on a constant supply of prosurvival signals from their microenvironment. When trophic factors become limited by injury or disease, cells undergo apoptosis." "This study establishes the regulation and function of Bim, Bak, and Bax in this response. MBA-15.4 murine ostcoblasts and primary human bone marrow stromal cells (hBMSCs) were subjected to growth factor depletion by serum starvation (1% FCS or serum withdrawal). Protein phosphorylation, activation, or expression was quantified by Western blotting and gene expression by real-time PCR. Regulation of apoptosis in response to serum...
Source: Gene Therapy Weekly (2008-07-17)
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