Gene Therapy Weekly
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Gene Therapy
Studies from University of Santiago have provided new data on gene therapy
July 17th, 2008
"Gene transfer is considered to be a promising alternative for the treatment of several chronic diseases that affect the ocular surface. The goal of the present work was to investigate the efficacy and mechanism of action of a novel DNA nanocarrier made of hyaluronan ( HA) and chitosan ( CS), specifically designed for topical ophthalmic gene therapy," scientists in Spain report. "With this goal in mind, we first evaluated the transfection efficiency of the plasmid DNA-loaded nanoparticles in a human corneal epithelium cell model. Second, we investigated the bioadhesion and internalization of the nanoparticles in the rabbit ocular epithelia by confocal laser scanning...
Source: Gene Therapy Weekly (2008-07-17)
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