Leukemia Gene Therapy

Scientists at Peking University publish new data on leukemia gene therapy

Published in Gene Therapy Weekly, July 17th, 2008

According to recent research from Beijing, People's Republic of China, "PDCD5 (programmed cell death 5) accelerates apoptosis of certain tumor cells and is expressed at low levels in marrow-nucleated cells of AML and CML patients. In the present study, we evaluated the effects of PDCD5 overexpression on drug sensitivity of leukemia cells."

"K562 cells were treated with idarubicin (IDR) alone or in combination with adenoviral vectors expressing PDCD5 (Ad-PDCD5). As shown by annexin-V-FITC/PI dual labeling, apoptosis rates were markedly increased after combined treatment with Ad-PDCD5 compared to IDR treatment alone. We observed that PDCD5 overexpression significantly...

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Source: Gene Therapy Weekly (2008-07-17)

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