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Asthma
New findings from National Taiwan University describe advances in asthma
July 17th, 2008
"Interleukin- 5 (IL-5) has been suggested to be involved in the development of airway hyper-responsiveness (AHR). Both clinical and experimental investigations have shown strong correlation between the presence of eosinophils and AHR," scientists writing in the journal Gene Therapy report. "In this study, we used small interfering RNA ( siRNA) as an approach to inhibiting the expression of IL-5 and reducing AHR. siRNAs targeting IL-5 were characterized in vitro, and siRNA- expressing lentiviruses were administered intratracheally to OVA-sensitized BALB/c mice. AHR, cytokine levels, serum levels of OVA-specific antibodies and infiltration of inflammatory cells...
Source: Gene Therapy Weekly (2008-07-17)
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