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Kidney Cancer

Studies from University of California have provided new data on kidney cancer

Published in Gene Therapy Weekly, July 31st, 2008

According to recent research from the United States, "Kidney cancer is notoriously difficult to treat when metastatic due to its resistance to conventional chemotherapy. Thus, the 5-year survival rate in patients with metastatic renal cell carcinoma is less than 10% and novel approaches to treatment are needed."

"The cyclin kinase inhibitor p21 generally conveys an anti-apoptotic function through its induction by the DNA damage responsive p53 pathway. We capitalized on this function of p21 and used an antisense approach to sensitize p53-wt renal cell carcinoma cells to chemotherapy induced apoptosis by attenuating p21 protein levels. The human renal cell carcinoma cell...

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