Gene Therapy

Researchers from University of California report recent findings in gene therapy

Published in Gene Therapy Weekly, July 31st, 2008

"In vivo lung-targeted VEGF gene inactivation results in pulmonary cell apoptosis, airspace enlargement, and increased lung compliance consistent with an emphysema-like phenotype. The predominant hypothesis for the cause of lung destruction in emphysema is an imbalance between active lung protease and anti-protease molecules," researchers in the United States report.

"Therefore, we investigated the role of protease (e.g., matrix metal loproteinases-MMPs) and anti-protease (e.g., tissue inhibitors of metalloproteinases-TIMPs) expression in contributing to the lung structural remodeling observed in pulmonary-VEGF-deficient mice. VEGFLoxPmice instilled through the trachea...

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Source: Gene Therapy Weekly (2008-07-31)

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