Neuropathic Pain

Studies from AstraZeneca further understanding of neuropathic pain

Published in Gene Therapy Weekly, July 31st, 2008

According to a study from Montreal, Canada, "Neuropathic pain remains one of the most challenging of all neurological diseases and presents a large unmet need for improved therapies. Many mechanistic details are still lacking, but greater knowledge of overlapping mechanisms and disease comorbidities has highlighted key areas for intervention."

"These include peripheral and central hyperexcitability. Among the molecular drivers are ion channels (Nav1.7, Nav1.8, Nav1.3, Cav2.2, and alpha2-delta subunits) whose expression is changed during neuropathic pain and their block shows therapeutic utility. Block of a number of ligand-gated channels [transient receptor potential...

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Source: Gene Therapy Weekly (2008-07-31)

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