Breast Cancer

Studies conducted at Florida Atlantic University on breast cancer recently published

Published in Gene Therapy Weekly, July 31st, 2008

"Brother of the regulator of imprinted sites (BORIS) is an epigenetically acting transcription factor which represses the tumor inhibitor functions of the tumor suppressor protein CTCF. BORIS expression has not been documented in adult females, making it an exciting molecular target for drug development in breast cancer," investigators in the United States report.

"Previously, we demonstrated that vaccination of mice with zing-finger (ZF)-deleted non-functional BORIS results in regression of breast cancer and generation of potent anti-tumor immune responses. RNAi induction can be used as an alternative approach for selective tumor cell killing. Short interfering RNA...

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Source: Gene Therapy Weekly (2008-07-31)

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