Cancer Gene Therapy
Research data from B. Couderc and colleagues update understanding of cancer gene therapy
Published in Gene Therapy Weekly, July 31st, 2008
"Using preclinical ovarian cancer models, we aimed to evaluate the potential use of RhoB cDNA as a tumor suppressor gene in gene therapy. RhoB restoration in vitro, through recombinant adenovirus transduction, resulted in the apoptosis of endogenous RhoB protein low-expressing cell lines (OVCAR-3 and IGROV-1) through the activation of the intrinsic apoptotic caspase cascade. We showed that a single injection of 10(8)...
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Source: Gene Therapy Weekly (2008-07-31)
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