Luciferase
Studies from University of North Carolina, Medical Department further understanding of luciferase
Published in Gene Therapy Weekly, August 7th, 2008
According to recent research published in the journal Nucleic Acids Research, "We describe the synthesis and characterization of a 5 conjugate between a 2-O-Me phosphorothioate antisense oligonucleotide and a bivalent RGD (arginineglycineaspartic acid) peptide that is a high-affinity ligand for the alpha v beta 3 integrin. We used alpha v beta 3-positive melanoma cells transfected with a reporter comprised of the firefly luciferase gene interrupted by an abnormally spliced intron."
"Intranuclear delivery of a specific antisense oligonucleotide (termed 623) corrects splicing and allows luciferase expression in these cells. The RGD623 conjugate or a cationic...
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Source: Gene Therapy Weekly (2008-08-07)
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