Gene Therapy
Researchers from University of Oklahoma report recent findings in gene therapy
Published in Gene Therapy Weekly, August 7th, 2008
According to recent research from the United States, "The stringent response to amino acid starvation, whereby stable RNA synthesis is curtailed in favour of transcription of amino acid biosynthetic genes, is controlled by the alarmone ppGpp. To elucidate the extent of gene expression effected by ppGpp, we designed an experimental system based on starvation for isoleucine, which could be applied to both wild-type Escherichia coli and the multiauxotrophic relA spoT mutant (ppGpp(0))."
"We used microarrays to profile the response to amino acid starvation in both strains. The wild-type response included induction of the general stress response, downregulation of genes...
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Source: Gene Therapy Weekly (2008-08-07)
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