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Carcinoma
Report summarizes carcinoma study findings from A. Ruddell and co-researchers
August 14th, 2008
"The ability of tumor cells to metastasize is increasingly viewed as an interaction between the primary tumor and host tissues. Deletion of the p19/Arf or p53 tumor suppressor genes accelerates malignant progression and metastatic spread of 7,12-dimethylbenz(a) anthracene (DMBA)/12-O-tetradecanoyl-phorbol-13-acetate (TPA)induced squamous cell carcinomas, providinga model system to address mechanisms of metastasis," scientists in the United States report. "Here, we show that benign pre-metastatic papillomas from wildtype mice trigger lymphangiogenesis within draining lymph nodes, whereas there is no growth of primary tumor lymphatic vessels. Lymph node lymphangiogenesis...
Source: Gene Therapy Weekly (2008-08-14)
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