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Hepatocellular Cancer

Scientists at Institute Pasteur target hepatocellular cancer

Published in Gene Therapy Weekly, August 14th, 2008

Data detailed in 'Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure' have been presented. "Hepatocellular carcinoma (HCC) is a heterogeneous disease triggered by various risk factors and frequently characterized by chromosome instability. This instability is considered to be caused primarily by Hepatitis B virus (HBV), although aflatoxin B1 (AFB1), a potent fungal mutagen is also suspected to influence chromosomal repair," investigators in France report.

"We studied 90 HCCs from Italy, the country with the highest incidence of hepatocellular carcinoma in Europe, 81 samples from France and 52 specimens from Shanghai, in...

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