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Colitis
Research results from P. Ergang and colleagues update understanding of colitis
August 14th, 2008
According to recent research published in the journal Digestive Diseases and Sciences, "Recent in vitro studies have shown the involvement of pro-inflammatory cytokines in the regulation of the local metabolism of glucocorticoids via 11 beta-hydroxysteroid dehydrogenase type 1 and type 2 (11HSD1 and 11HSD2). However, direct in vivo evidence for a relationship among the local metabolism of glucocorticoids, inflammation and steroid enzymes is still lacking." "We have therefore examined the changes in the local metabolism of glucocorticoids during colonic inflammation induced by TNBS and the consequences of corticosterone metabolism inhibition by carbenoxolone on...
Source: Gene Therapy Weekly (2008-08-14)
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