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Gene Therapy
Data from Kyushu University advance knowledge in gene therapy
August 14th, 2008
"Cytochrome P450 2E1 (CYP2E1) is clinically and toxicologically important and exhibits 24-hoar periodicity in its activity. In the present study, we investigated whether hepatic nuclear factor-1 alpha (HNF-1 alpha) and clock genes with a striking 24-hour rhythm in mouse liver contributed to the 24-hour regulation of CYP2E1 expression," scientists writing in the journal Hepatology report. "The results demonstrated that the expression of CYP2E1 messenger RNA (mRNA) in the liver was affected by HNF-1 alpha and the circadian organization of molecular docks. The mRNA levels of CYP2E1 in the liver increased from the late light phase to the early dark phase. Luciferase...
Source: Gene Therapy Weekly (2008-08-14)
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