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Gene Therapy
New gene therapy study findings recently were reported by C. Turecek and co-researchers
August 14th, 2008
"Osteoblasts synthesize collagen matrix, which itself regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase (LOX), which is involved in the collagen cross-linking process," scientists in Vienna, Austria report. "Lathyrogens, like beta-aminopropionitrile (beta APN), inhibit the formation of a stable matrix. The aim of the present study was to investigate the influence of cross-linking on osteoblastic differentiation. MC3T3-E1 cells were seeded and treated with or without 400 mc M beta APN for 1 week. Thereafter, living cells were removed and, on this extracellular matrix, new MC3T3-E1 cells were seeded and cultured for 1...
Source: Gene Therapy Weekly (2008-08-14)
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