Gene Therapy Weekly
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Gene Therapy
Reports from Columbia University highlight recent research in gene therapy
August 14th, 2008
According to a study from the United States, "The receptor for advanced glycation end-products (RAGE) is a single-transmembrane, multiligand receptor of the immunoglobulin superfamily. RAGE up-regulation is implicated in numerous pathological states including vascular disease, diabetes, cancer, and neurodegeneration." "The understanding of the regulation of RAGE is important in both disease pathogenesis and normal homeostasis. Here, we demonstrate the characterization and identification of human RAGE splice variants by analysis of RAGE cDNA from tissue and cells. We identified a vast range of splice forms that lead to changes in the protein coding region of RAGE, which...
Source: Gene Therapy Weekly (2008-08-14)
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