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Gene Therapy Weekly

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Gene Therapy



Reports on gene therapy findings from Hokkaido University provide new insights



August 14th, 2008

"Nucleic acids possess charged phosphate groups in their backbones, which require counterions to reduce the repulsive Coulombic interactions between the strands. Herein we report how different mono-and divalent metal cations influence the molecular orientations of DNA molecules on silicon surfaces upon immobilization and hybridization," scientists writing in the Journal of the American Chemical Society report.

"Our sum frequency generation (SFG) spectroscopy studies demonstrated that the degree of conformational variation of DNA self-assembled monolayers on silicon depends on the type of metal cations present. The molecular orientation change of immobilized...


Source: Gene Therapy Weekly (2008-08-14)

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