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Gene Therapy
Reports outline gene therapy study results from University of Missouri, Medical Department
August 14th, 2008
"Reduction of plasma cholesterol by citrus flavonoids is associated with effects on specific liver functions related to lipid handling. In previous in vivo studies, polymethoxylated flavones (PMF) reduced plasma cholesterol levels at lower doses than required for flavanones," researchers in the United States report. "To delineate hepatic mechanisms that underlie this differential potency, we used HepG2 cells to quantitate effects on expression of the LDL receptor (LDLR) gene. A dose-response analysis showed that 200 mu mol/L hesperetin, a flavanone present as a disaccharide in oranges, increased LDLR mRNA levels 3.6-to4.7-fold of the untreated control. In contrast,...
Source: Gene Therapy Weekly (2008-08-14)
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