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Gene Therapy
Research data from University of Nice update understanding of gene therapy
August 14th, 2008
According to a study from Valbonne, France, "The presenilin (PS)-dependent gamma-secretase activity refers to a high molecular mass-complex including, besides PSI or PS2, three other proteins recently identified, namely nicastrin Aph-1, and Pen-2. This proteolytic complex has been shown to contribute to both gamma- and c-cleavages of the beta-amyloid precursor protein (beta APP), thereby generating beta-amyloid peptides (AP) and the APP intracellular domain (AICD), respectively." "TMP21, a member of the p24 cargo protein family, was recently shown to interact with PS complexes. Interestingly, TMP21 modulates gamma-secretase-inediated A beta production but does not...
Source: Gene Therapy Weekly (2008-08-14)
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