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Gene Therapy
Research from G. Disegni et al has provided new information about gene therapy
August 14th, 2008
According to a study from Monterotondo, Italy, "The formation of chimeric mRNAs; is a strategy used by human cells to increase the complexity of their proteome, as revealed by the ENCODE project. Here, we use Saccharomyces cerevisiae to show a way by which trans-spliced mRNAs can be generated." "We demonstrate that a pretRNA inserted into a premRNA context directs the splicing reaction precisely to the sites of the tRNA intron. A suppressor pretRNA gene was inserted, in cis, into the sequence encoding the third cytoplasmic loop of the Ste2 or Ste3 G protein-coupled receptor. The hybrid RNAs are spliced at the specific pretRNA splicing sites, releasing both functional...
Source: Gene Therapy Weekly (2008-08-14)
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