Gene Therapy Weekly
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Gene Therapy
Research reports from University of Kentucky provide new insights into gene therapy
August 14th, 2008
"Wnt proteins control cell fate and differentiation during development. Alterations of the Wnt/beta-catenin signaling pathway and changes in wnt gene expression are clearly associated with leukemia," scientists in the United States report. "The expression of human wnt13/wnt2b is complex as it involves alternative promoters and RNA splicing giving rise to Wnt13A, -B and -C mRNA isoforms, which encode proteins with different intracellular localizations and functions. We investigated the expression of the human wnt13 in relation to leukemic cell differentiation. Differentiated endothelial cells expressed the highest levels of Wnt13 mRNA isoforms among various endothelial...
Source: Gene Therapy Weekly (2008-08-14)
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