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Gene Therapy
Scientists at University of Michigan release new data on gene therapy
August 14th, 2008
According to recent research published in the journal Nucleic Acids Research, "Understanding transcriptional regulation is a major goal of molecular biology. Motif expression decomposition (MED) was recently introduced to describe the expression level of a gene as the sum of the products of the binding strengths of its cis-regulatory motifs and the activities of the corresponding trans-acting transcription factors (TFs)." "Here, we use computer simulation to examine the accuracy of MED. We found that although MED accurately rebuilds gene expression levels from decomposed motif binding strengths and TF activities, estimates of motif binding strengths and TF...
Source: Gene Therapy Weekly (2008-08-14)
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