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Hepatitis C Virus
Research from Ehime University, Medical Department yields new data on hepatitis C virus
August 14th, 2008
According to a study from Japan, "A derivative of soyasapogenol, 22 beta-methoxyolean-12-ene-3 beta, 24(4 beta)-diol (ME3738), ameliorates liver injury induced by Concanavalin A in mice. We examined whether ME3738 has independent antiviral effects against hepatitis C virus (HCV) using an established HCV replication model that expresses the full-length genotype 1a HCV complementary DNA plasmid (pT7-flHCV-Rz) under the control of a replication-defective adenoviral vector expressing T7 polymerase." "Hepatocellular carcinoma (HepG2) cells, human hepatoma (Huh7) cells, or monkey kidney (CV-1) cells were transfected with pT7-flHCV-Rz, and infected with adenoviral vector...
Source: Gene Therapy Weekly (2008-08-14)
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