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Human Papillomavirus
New research on human papillomavirus from I. Ammermann and co-authors summarized
August 14th, 2008
According to a study from Tubingen, Germany, "Papillomavirus genomes replicate as nuclear plasmids at a low copy number in undifferentiated keratinocytes. Papillomaviruses encode the E1 and E2 proteins that bind to the origin of replication and are required for the activation of replication." "In addition to E2, several papillomaviruses express an E8(Lambda)E2C protein, which is generated by alternative splicing and functions as a transcriptional repressor and inhibitor of the E1/E2-dependent replication of the viral origin. Previous analyses suggested that the E8 domain functions as a transferable repression domain. In this report we present evidence that the E8 domain...
Source: Gene Therapy Weekly (2008-08-14)
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