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Kidney Disease
Investigators at University of Hong Kong, Medical Department target kidney disease
August 14th, 2008
According to recent research from Hong Kong, People's Republic of China, "Increasing evidence shows that transforming growth factor-beta TGF-beta 1 (TGF-beta 1) is upregulated and plays a diverse role in renal fibrosis by stimulating extracellular matrix (ECM) production, while inhibiting renal inflammation. Recent studies have identified that TGF-beta 1, once activated, signals through its downstream signaling pathway to exert its biological effects." "It is now well accepted that TGF-beta regulates fibrosis positively by receptor-associated Smads including Smad2 and Smad3, but negatively by an inhibitory Smad, called Smad7. We and other investigators have shown that...
Source: Gene Therapy Weekly (2008-08-14)
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