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Life Sciences
New life sciences data have been reported by N. Ronkina and co-authors
August 14th, 2008
"The MAPK-activated protein kinases MK2 and MK3 form a pair of structurally and functionally closely related enzymes present in mammals and birds. Both protein kinases can bind to p38a MAPK and are activated by p38a via multiple proline-directed phosphorylations in a stress-dependent manner," scientists in Hannover, Germany report. "Although the expression level and activity of MK2 is always significantly higher than that of MK3, the substrate spectrum of both enzymes is indistinguishable and covers proteins involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling and transcriptional...
Source: Gene Therapy Weekly (2008-08-14)
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