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Life Sciences
Reports from M. Sioud and co-researchers add new data to research in life sciences
August 14th, 2008
According to recent research from Oslo, Norway, "The innate immune system uses pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) to recognize conserved pathogen-associated molecular patterns (PAMPs) expressed by microbes and to activate the initial phase of immune response. Both bacterial and viral nucleic acids activate TLRs resulting in cytokines and interferon production." "Recent studies indicated that unmodified small interfering RNAs (siRNAs) corresponding to either mammalian (self) or microbial (non-self) RNA sequences can activate immunity through TLR7/8 in a sequence-dependent manner. Hence, the use siRNAs in humans will require...
Source: Gene Therapy Weekly (2008-08-14)
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