Bipolar Disorder
New bipolar disorder study findings reported from Columbia University
Published in Gene Therapy Weekly, August 14th, 2008
According to recent research from the United States, "DISC1 is a strong candidate susceptibility gene for schizophrenia, bipolar disorder, and depression. Using a mouse strain carrying an endogenous Disc1 orthologue engineered to model the putative effects of the disease-associated chromosomal translocation we demonstrate that impaired Disc1 function results in region-specific morphological alterations, including alterations in the organization of newly born and mature neurons of the dentate gyrus."
"Field recordings at CA3/CA1 synapses revealed a deficit in short-term plasticity. Using a battery of cognitive tests we found a selective impairment in working memory (WM),...
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Source: Gene Therapy Weekly (2008-08-14)
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