Fanconi Anemia

Reports outline fanconi anemia study findings from National Institute on Aging

Published in Gene Therapy Weekly, August 21st, 2008

According to recent research from the United States, "In response to DNA damage, the Fanconi anemia (FA) core complex functions as a signaling machine for monoubiquitination of FANCD2 and FANCI. It remains unclear whether this complex can also participate in subsequent DNA repair."

"We have shown previously that the FANCM constituent of the complex contains a highly conserved helicase domain and an associated ATP-dependent DNA translocase activity. Here we show that FANCM also possesses an ATP-independent binding activity and an ATP-dependent bi-directional branch-point translocation activity on a synthetic four-way junction DNA, which mimics intermediates generated...

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Source: Gene Therapy Weekly (2008-08-21)

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