Gene Therapy

New gene therapy study findings recently were reported by researchers at University of Pennsylvania, Medical Department

Published in Gene Therapy Weekly, August 21st, 2008

"Gene transfer has been used to correct inherited immunodeficiencies, but in several patients integration of therapeutic retroviral vectors activated proto-oncogenes and caused leukemia. Here, we describe improved methods for characterizing integration site populations from gene transfer studies using DNA bar coding and pyrosequencing," scientists writing in the journal Nucleic Acids Research report.

"We characterized 160 232 integration site sequences in 28 tissue samples from eight mice, where Rag1 or Artemis deficiencies were corrected by introducing the missing gene with gamma-retroviral or lentiviral vectors. The integration sites were characterized for...

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Source: Gene Therapy Weekly (2008-08-21)

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