Gene Therapy

Reports by A. Kassem and co-researchers describe recent advances in gene therapy

Published in Gene Therapy Weekly, August 21st, 2008

According to recent research from Freiburg, Germany, "Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of the elderly or immunosuppressed patients. Recently, the clonal integration of a new human polyoma virus, which was termed Merkel cell polyomavirus (MCPyV), has been reported in 8 of 10 MCC patients."

"In the present study, we studied the formalin-fixed and paraffin-embedded tissue specimens of 39 MCC for the presence of MCPyV by PCR. We applied four different primer sets directed against the large T antigen and the VP1 gene of MCPyV. We were able to detect MCPyV in 77% (n = 30) of MCC as confirmed by sequence analyses of the PCR products....

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Source: Gene Therapy Weekly (2008-08-21)

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