Arteriovenous Malformation
Research on arteriovenous malformation detailed by scientists at University of California
Published in Gene Therapy Weekly, August 21st, 2008
"The transgenic arteriovenous fistula model, surgically constructed with transgenic mouse aorta interposed in common carotid artery-to-external jugular vein fistulae in nude rats, has 4-month experimental window because patency and transgenic phenotype are lost over time. We adapted this model to investigate occlusive arteriopathy in brain arteriovenous malformations after radiosurgery by radiating grafted aorta before insertion in the fistula," scientists in the United States report.
"We hypothesized that high-dose radiation would reproduce the arteriopathy observed clinically within the experimental time window and that deletions of endoglin (ENG) and endothelial...
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Source: Gene Therapy Weekly (2008-08-21)
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