Gonorrhea

New gonorrhea research from D.L. Garcia et al outlined

Published in Gene Therapy Weekly, August 21st, 2008

According to recent research published in the Journal of Bacteriology, "Neisseria gonorrhoeae releases peptidoglycan fragments during growth. The majority of the fragments released are peptidoglycan monomers, molecules known to increase pathogenesis through the induction of proinflammatory cytokines and responsible for the killing of ciliated epithelial cells."

"In other gram-negative bacteria such as Escherichia coli, these peptidoglycan fragments are efficiently degraded and recycled. Peptidoglycan fragments enter the cytoplasm from the periplasm via the AmpG permease. The amidase AmpD degrades peptidoglycan monomers by removing the disaccharide from the...

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Source: Gene Therapy Weekly (2008-08-21)

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