Cancer Gene Therapy
Researchers from Eberhard-Karls University, Department of Radiation Oncology report details of new studies and findings in the area of cancer gene therapy
Published in Gene Therapy Weekly, August 21st, 2008
Investigators publish new data in the report 'Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.' According to a study from Germany, "We have already reported that epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT signaling is an important pathway in regulating radiation sensitivity and DNA double-strand break (DNA-dsb) repair of human tumor cells. In the present study, we investigated the effect of AKT1 on DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity and DNA-dsb repair in irradiated non-small cell lung cancer cell lines A549 and H460."
"Treatment of...
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Source: Gene Therapy Weekly (2008-08-21)
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