Gene Therapy
Chang Gung Memorial Hospital, Department of Dentistry describes research in gene therapy
Published in Gene Therapy Weekly, August 21st, 2008
New research, 'Thrombin activates Ras-CREB/ATF-1 signaling and stimulates c-fos, c-jun, and c-myc expression in human gingival fibroblasts,' is the subject of a report. According to a study from Taipei, Taiwan, "Protease-activated receptors (PARs) can be stimulated by thrombin and other proteases generated by periodontal pathogens. Activation of PARs in gingival fibroblasts (GFs) can modulate wound healing and inflammatory responses in gingival tissues."
"The mRNA expression of PARs and early responsive genes in GFs and other oral cells was studied by reverse transcription-polymerase chain reaction. Western blotting was used to study the activation of p38 and cAMP...
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Source: Gene Therapy Weekly (2008-08-21)
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