Published in Gene Therapy Weekly, August 28th, 2008
"We generated SOST knockout (KO) mice to gain a more detailed understanding of the effects of sclerostin deficiency on bone. Gene targeting was used to inactivate SOST and generate a line of SOST KO mice. Radiography, densitometry, mu CT, histomorphometry, and mechanical testing were used to characterize the impact of sclerostin deficiency on bone in male and female mice. Comparisons were made...
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