Cancer Gene Therapy
Scientists at University of Helsinki report research in cancer gene therapy
Published in Gene Therapy Weekly, August 28th, 2008
"We hypothesized that changing the fiber knob could overcome NAb. Immune-competent mice were exposed to serotype 5 adenovirus (Ad5)(GL), Ad5/3luc1, Ad5lucRGD or Ad5pK7(GL). Mice immunized with Ad5(GL) featured reduced intravenous Ad5(GL) gene transfer to most organs, including the liver, lung and spleen. Ad5(GL) gene transfer was affected much less by exposure to capsid-modified viruses....
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Source: Gene Therapy Weekly (2008-08-28)
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