DNA Research
Research from J.M. Kim and co-authors yields new data on DNA research
Published in Gene Therapy Weekly, August 28th, 2008
"In this study, we show that deletion of the Cdc7 genes in mouse embryonic stem (ES) cells abrogates hydroxyurea (HU)- or UV-induced activation of Chk1. HU-induced Chk1 activation is also impaired in human cancer cell lines in which Cdc7 is depleted by siRNA, and Cdc7-depleted cells are more sensitive to HU treatment. In contrast, ATR and Rad17 are relocated to chromatin in these cells following HU treatment, indicating that stalled DNA replication forks...
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Source: Gene Therapy Weekly (2008-08-28)
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