Published in Gene Therapy Weekly, September 4th, 2008
"C-MYC and DHFR protein levels at diagnosis were assessed by immunohistochemistry on series of patients treated with either a MTX-based protocol (IOR/OS-1; 72 patients) or with a standard four-drug regimen (ISG/SSG 1; 61 patients). Down-regulation of C-MYC significantly decreased the MTX resistance level of OS cells, demonstrating its causal...
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