Osteosarcoma

Reports summarize osteosarcoma study results from I. Scionti and co-researchers

Published in Gene Therapy Weekly, September 4th, 2008

According to a study from Bologna, Italy, "Aims of this study were the validation of C-MYC involvement in methotrexate (MTX) resistance and the assessment of clinical impact of C-MYC and dihydrofolate reductase (DHFR) in osteosarcoma (OS). The involvement of C-MYC in MTX resistance was validated with an antisense approach."

"C-MYC and DHFR protein levels at diagnosis were assessed by immunohistochemistry on series of patients treated with either a MTX-based protocol (IOR/OS-1; 72 patients) or with a standard four-drug regimen (ISG/SSG 1; 61 patients). Down-regulation of C-MYC significantly decreased the MTX resistance level of OS cells, demonstrating its causal...

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Source: Gene Therapy Weekly (2008-09-04)

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