Gene Therapy

Scientists at St. James University discuss research in gene therapy

Published in Gene Therapy Weekly, September 4th, 2008

"Genotype-specific cancer therapy promises to engender the era of personalised medicines in which rapid identification of tumour specific gene mutations coupled to rapid methods for efficacious drug identification will be applied. Aberrant signal transduction via protein-protein interactions is generally difficult to target with small molecules," scientists in Leeds, the United Kingdom report.

"However, macromolecules (macrodrugs) can be developed that interfere with protein-protein interactions by binding with high affinity and specificity to contact surfaces. Inhibitors of mutant RAS and its effector protein interactions affect cancer by attenuating aberrant...

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Source: Gene Therapy Weekly (2008-09-04)

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