Cancer

New cancer study findings have been reported by researchers at Boehringer Ingelheim GmbH

Published in Gene Therapy Weekly, September 4th, 2008

"invasion and metastasis of malignant epithelial cells into normal tissues is accompanied by adaptive changes in the mesenchyme-derived supporting stroma of the target organs. Altered gene expression in these nontransformed stromal cells provides potential targets for therapy," researchers in Vienna, Austria report.

"The present study was undertaken to determine the antitumor effects of an antibody-conjugate against fibroblast activation protein-alpha, a cell surface protease of activated tumor fibroblasts. A novel antibody-maytansinoid conjugate, monoclonal antibody (mAb) FAP5-DM1, was developed to target a shared epitope of human, mouse, and cynomolgus monkey...

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Source: Gene Therapy Weekly (2008-09-04)

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