Published in Gene Therapy Weekly, September 11th, 2008
"Pten(+/-) mice are currently being used as a model to study EMC. These females develop atypical endometrial hyperplasia of which similar to 20% progresses to EMC. In addition, tumors develop in other organs, complicating the use of this model to specifically study EMC. Here, we show that conditional deletion of endometrial Pten results in EMC in all female mice as early as age 1 month with myometrial invasion occurring by 3...
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