Gene Therapy

Researchers from Duke University provide details of new studies and findings in the area of gene therapy

Published in Gene Therapy Weekly, September 11th, 2008

"PUF family proteins are among the best-characterized regulatory RNA-binding proteins in nonmammalian species, but relatively little is known about mRNA targets or functions of mammalian PUF proteins. In this study, we used ribonomic analysis to identify and analyze mRNAs associated with ribonucleoproteins containing an endogenous human PUF protein, Pum1," scientists in the United States report.

"Pum1-associated mRNAs were highly enriched for genes encoding proteins that function in transcriptional regulation and cell cycle/proliferation, results consistent with the posttranscriptional RNA regulon model and the proposed ancestral functions of PUF proteins in stem cell...

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Source: Gene Therapy Weekly (2008-09-11)

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