Ovarian Cancer

Research reports from Harvard University provide new insights into ovarian cancer

Published in Gene Therapy Weekly, September 11th, 2008

"Among the proinflammatory mediators, platelet-activating factor (PAF, 1-o-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a major primary and secondary messenger involved in intracellular and extracellular communication. Evidence suggests that PAF plays a significant role in oncogenic transformation, tumor growth, angiogenesis, and metastasis," scientists in the United States report.

"However, PAF, with its receptor (PAFR) and their downstream signaling targets, has not been thoroughly studied in cancer. Here, we characterized the PAFR expression pattern in 4 normal human ovarian surface epithelial (HOSE) cell lines, 13 ovarian cancer cell lines, paraffin blocks (n =...

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Source: Gene Therapy Weekly (2008-09-11)

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