Apoptosis

Reports from University of Dusseldorf advance knowledge in apoptosis

Published in Gene Therapy Weekly, September 18th, 2008

"Upon encounter with pathogens, T cells activate several defense mechanisms, one of which is the up-regulation of CD95 ligand (CD95UFasL) which induces apoptosis in sensitive target cells. Despite expression of the CD95 receptor, however, recently activated T cells are resistant to CD95L, presumably due to an increased expression of antiapoptotic molecules," scientists writing in the journal Blood report.

"We show here that, in contrast to naive or long-term activated T cells, short-term activated T cells strongly upregulate the caspase-8 inhibitor, cellular FLICE-inhibitory protein (c-FLIP). Intriguingly, upon activation, T cells highly induced the short splice...

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Source: Gene Therapy Weekly (2008-09-18)

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