Gene Therapy

Research from B. Krampe and co-authors yields new data on gene therapy

Published in Gene Therapy Weekly, September 18th, 2008

"A combined gene and protein expression profiling was performed to gain a deeper insight into the intracellular response of the antibody-producing GS-NS0 cell line in continuous perfusion culture. Growth rate, production rate, metabolic activity and viability declined with increasing cell density, dilution rate and time," researchers in Dublin, Ireland report.

"Transcriptome and protecime analyses of cells at three different densities revealed 53 genes and 47 proteins as having significantly altered expression levels at HCD (high cell density). The results showed an increased up-regulation of genes/proteins involved in cellular energy production with increasing cell...

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Source: Gene Therapy Weekly (2008-09-18)

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